Blood-Based Glutamate Scavengers Reverse Traumatic Brain Injury-Induced Synaptic Plasticity Disruption by Decreasing Glutamate Level in Hippocampus Interstitial Fluid, but Not Cerebral Spinal Fluid, In Vivo.

PMID 30255425 ↗2018Reported benefit

Blood-Based Glutamate Scavengers Reverse Traumatic Brain Injury-Induced Synaptic Plasticity Disruption by Decreasing Glutamate Level in Hippocampus Interstitial Fluid, but Not Cerebral Spinal Fluid, In Vivo.

RatTBIUnspecifiedWistarMaleAdministered acutely after induction of TBI, with synaptic plasticity assessed…

Model: Experimental traumatic brain injury in rats with in vivo assessment of hippocampal long-term potentiation and microdialysis of hippocampal interstitial fluid and ventricular CSF; specific impact model not stated in the abstract

Repeated dosing of rGOT1 with oxaloacetate induced a persistent increase in serum GOT and reversed the TBI-induced disruption of synaptic plasticity 4 days after injury. The reversal of LTP inhibition was associated with a fall in glutamate in hippocampal interstitial fluid but not in ventricular C…

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Blood-Based Glutamate Scavengers Reverse Traumatic Brain Injury-Induced Synaptic Plasticity Disruption by Decreasing Glutamate Level in Hippocampus Interstitial Fluid, but Not Cerebral Spinal Fluid, In Vivo.

Evidence by therapy association

Blood-Based Glutamate Scavengers Reverse Traumatic Brain Injury-Induced Synaptic Plasticity Disruption by Decreasing Glutamate Level in Hippocampus Interstitial Fluid, but Not Cerebral Spinal Fluid, In Vivo.