Multipotent Adult Progenitor Cells, but Not Tissue Inhibitor of Matrix Metalloproteinase-3, Increase Tissue Sparing and Reduce Urological Complications following Spinal Cord Injury.

Multipotent Adult Progenitor Cells, but Not Tissue Inhibitor of Matrix Metalloproteinase-3, Increase Tissue Sparing and Reduce Urological Complications following Spinal Cord Injury.

Model: Contusion spinal cord injury

Intravenous MAPC delivered 1 day after injury significantly improved tissue sparing and affected functional recovery, and reduced the incidence of urinary tract infection and antibiotic use. TIMP3 gave no significant benefit and abrogated the therapeutic effect of MAPC when co-administered

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