Purified PEGylated human glucagon-like peptide-2 reduces the severity of irradiation-induced acute radiation enteritis in rats.
RatRadiationSprague-DawleyMalen = 60 adult male rats randomised into six groupsIntraperitoneal injection3 microgram (low), 10 microgram (middle) and 30 microgram (…Described as pretreatment, although methods state irradiated rats recovered fro…
Model: Single 8 Gy abdominopelvic X-ray irradiation producing acute radiation enteritis, delivered at 0.74 Gy/min with the rest of the body shielded
Mono-PEG-hGLP-2 resisted DPP-IV degradation (26.7% intact at 1 h versus 5% for unmodified GLP-2) and dose-dependently preserved villus number and height and crypt height (villus height 507.9 +/- 21.1 micrometre at 30 microgram versus 233.1 +/- 14.8 micrometre in irradiated controls and 543.1 +/- 26…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.