Inhibitory role of lentivirus-mediated aquaporin-4 gene silencing in the formation of glial scar in a rat model of traumatic brain injury.
RatTBIUnspecifiedSprague-DawleyMaleAfter establishment of the traumatic brain injury model
Model: Rat model of traumatic brain injury, specific induction method not stated in abstract
At 7, 14 and 28 days after injury, rats treated with AQP4 shRNA showed improved neurological function and reduced histomorphological change, with decreased mRNA and protein expression of GFAP, vimentin, fibronectin and laminin and reduced positive cell counts, positive area ratio and glial scar for…
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