Overexpression of miR-381-3p promotes the recovery of spinal cord injury.
RatSpinal cord injuryUnspecifiedSprague-DawleyFemale per MeSH indexing
Model: Acute spinal cord injury rat model; parallel in vitro model of lipopolysaccharide-stimulated BV2 microglial cells
miR-381-3p was downregulated after acute spinal cord injury while IKKbeta and phospho-p65 were upregulated; miR-381-3p overexpression reduced IKKbeta, phospho-p65, TNF-alpha and IL-1beta and produced earlier recovery of grip ability, coordination and anti-fatigue performance, consistent with inhibi…
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