Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice.
MouseTBIControlled cortical impactC57Bl/6MaleIntracerebroventricular0.5 nmol for acute single administration; 0.5 nmol/day for…Acute arm given immediately after injury; delayed arm beginning 24 hours post-i…
Model: Controlled cortical impact traumatic brain injury
TBI robustly increased cortical and microglial/macrophage miR-155 expression; acute ICV antagomir attenuated neuroinflammatory markers at 1 and 7 days and reduced spatial working memory impairment, while delayed ICV infusion attenuated neuroinflammatory markers at 7 days, limited NOX2 changes, redu…
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