Uric Acid Treatment After Stroke Prevents Long-Term Middle Cerebral Artery Remodelling and Attenuates Brain Damage in Spontaneously Hypertensive Rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Wistar-Kyoto and spontaneously hypertensive ratsMalen = WKY n=36 and SHR n=37Intravenous16 mg/kg120 min after occlusion, during early reperfusion
Model: Transient intraluminal middle cerebral artery occlusion for 90 min followed by reperfusion for 1 to 15 days
SHR rats sustained more severe brain damage and poorer neurofunctional outcomes than WKY rats, coupled to higher cortical cerebral blood flow at reperfusion onset, a transient rise in oxidative stress and long-lasting hypertrophic remodelling of the middle cerebral artery. Uric acid given during ea…
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