Effects of Exendin-4 on pancreatic islets function in treating hyperglycemia post severe scald injury in rats.
RatBurnScaldWistarn = 162 adult rats equally randomised to three groups (54 per g…Subcutaneous injection4 micrograms per kgAfter scald injury
Model: Full skin thickness scald injury covering 50 per cent total body surface area
Exendin-4 reduced islet and beta-cell histopathological damage and apoptosis index, increased insulin and reduced glucagon in islets and plasma, and improved intraperitoneal glucose tolerance and fasting blood glucose (all P < 0.05).
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