A Synthetic Peptide AWRK6 Alleviates Lipopolysaccharide-Induced Liver Injury.
MouseEndotoxin/LPSKunmingFemaleIntraperitoneal injection in vivo; culture medium in vitro10 mg/kg in vivo; 20 to 200 micrograms/mL in vitro, with 20…1 hour after lipopolysaccharide administration
Model: Lipopolysaccharide-induced liver injury by intraperitoneal injection of LPS at 50 mg/kg; parallel in vitro model using HepG2 cells with LPS at 40 micrograms/mL
AWRK6 reversed LPS-induced elevation of alanine aminotransferase and inducible nitric oxide synthase and restored superoxide dismutase, reduced histological damage and neutrophil infiltration, lowered TUNEL-positive apoptosis with normalisation of cleaved caspase 9, Bax and Bcl-2, restored HepG2 vi…
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