Comparison of the detrimental features of microglia and infiltrated macrophages in traumatic brain injury: A study using a hypnotic bromovalerylurea.
RatTBIPenetrating / ballisticWistarMale
Model: Stab wound traumatic brain injury
Bromovalerylurea inhibited CCL2 expression, monocyte and macrophage accumulation, 8-hydroxy-2'-deoxyguanosine and mitochondrial reactive oxygen species generation and pro-inflammatory cytokine expression, and markedly improved outcome, without inhibiting microglial activation or TGF-beta1 and IGF-1…
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