Caspase-2 Mediates Site-Specific Retinal Ganglion Cell Death After Blunt Ocular Injury.
RatOtherLister-hoodedFemaleIntravitreal injection
Model: Bilateral ballistic closed globe blunt ocular trauma
Caspase-2 knockdown protected retinal ganglion cells around but not within the centre of the injury site and increased the amplitude of the photopic negative response at two weeks. It gave no protection to photoreceptors, indicating photoreceptor degeneration in this model is not caspase-2 mediated.
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