Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling.
MouseChemical/toxinWild-type C57BL/6 and Nrf2 knockout on C57BL backgroundMalen = 5 mice per group
Model: Severe acute pancreatitis induced by seven hourly intraperitoneal injections of cerulein 50 microgram/kg in 0.9 per cent sodium chloride, with lipopolysaccharide 10 mg/kg added to the last cerulein injection
Isoliquiritigenin reduced pancreatic and intestinal histological injury and cleaved caspase-3, lowered IL-6, TNF-alpha and malondialdehyde, raised superoxide dismutase, Nrf2, HO-1 and NQO-1, reduced NF-kB and restored IkB, and increased the intestinal junction proteins P120-catenin and occludin. Nr…
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