PRECLINICAL PUBLICATION · 2018

Pharmacokinetics and Preventive Effects of Sulfo-Albumin as a Novel Macromolecular Hydrogen Sulfide Prodrug on Carbon Tetrachloride-Induced Hepatic Injury.

Mouse / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Sulfo-albumin, a macromolecular hydrogen sulfide prodrug formed by covalent conjugation of multisulfide groups to bovine serum albumin

PMID 30156185 ↗2018Reported benefit

Pharmacokinetics and Preventive Effects of Sulfo-Albumin as a Novel Macromolecular Hydrogen Sulfide Prodrug on Carbon Tetrachloride-Induced Hepatic Injury.

MouseChemical/toxinMaleIntravenous injection

Model: Carbon tetrachloride induced acute liver injury

Hydrogen sulfide was released from sulfo-albumin only in the presence of 5 mM glutathione and inside cells rather than in plasma. Labelled sulfo-albumin accumulated predominantly in the liver in proportion to the number of sulfide groups after intravenous injection, and sulfo-albumin significantly…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.