The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response.
MouseChemical/toxinICRMaleIntragastric100 mg/kgPretreatment, for 15 days before carbon tetrachloride exposure; carbon tetrachl…
Model: Carbon tetrachloride-induced acute liver injury (single intraperitoneal injection of CCl4 0.25% in olive oil, 10 mL/kg body weight)
Maltol pretreatment lowered serum ALT and AST, reduced inflammatory mediator expression, suppressed hepatocyte apoptosis, attenuated the loss of catalase, glutathione and superoxide dismutase, reduced CYP2E1 and HO-1 over-expression, and improved liver histopathology after carbon tetrachloride expo…
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