A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase.
MouseHaemorrhage/shockUnspecifiedMaleIntraperitoneal0.2 mg/kgFirst dose at the time of intracerebral haemorrhage induction
Model: Intracerebral haemorrhage induced by injecting 25 microlitres of autologous blood collected from the jugular vein into the striatum
RS9 reduced brain oedema, improved neurological deficits, decreased neuronal damage area and upregulated HO-1 and SOD1 expression after intracerebral haemorrhage. In vitro it suppressed neuronal cell death and reactive oxygen species over-production, effects abolished by the HO-1 inhibitor zinc pro…
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