Modified Methacrylate Hydrogels Improve Tissue Repair after Spinal Cord Injury.
RatSpinal cord injuryHemisection / partialWistarMalen = 34 male Wistar rats in total across groupsIntraspinal implantation into the lesion cavityAcute, at the time of spinal cord injury
Model: Spinal cord hemisection at the T8 level with acute hydrogel implantation
HPMA and HEMA-Fn scaffolds produced partial sensory improvement compared with control and plain HEMA animals. HPMA showed increased connective tissue infiltration and significantly greater axonal ingrowth than HEMA-Fn and plain HEMA. HEMA-Fn showed a non-significant tendency towards greater connect…
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