Flufenamic acid inhibits secondary hemorrhage and BSCB disruption after spinal cord injury.
MouseSpinal cord injuryContusionC57BL/6 and Thy1-GFP-MFemalen = Three groups of n=12 animals per group; histological subana…Intraperitoneal injection12.5 mg/kgFirst dose 1 h after spinal cord injury
Model: Moderate contusion spinal cord injury at T10
Flufenamic acid reduced Trpm4 expression, secondary haemorrhage and capillary fragmentation, promoted angiogenesis, suppressed MMP-2 and MMP-9 at 1 day and attenuated blood-spinal cord barrier disruption at 1 and 3 days. It reduced microglia/macrophage activation, produced smaller lesions and less…
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