Xuebijing injection induces anti-inflammatory-like effects and downregulates the expression of TLR4 and NF-kappa B in lung injury caused by dichlorvos poisoning.
RatChemical/toxinSprague-DawleyMaleIntraperitoneal injectionAfter dichlorvos challenge
Model: Acute organophosphate pesticide poisoning induced lung injury by subcutaneous dichlorvos (DDVP) administration
Xuebijing injection attenuated dichlorvos-induced lung histopathological damage and improved PaO2/FiO2 ratios, reduced total cell, macrophage and neutrophil counts in bronchoalveolar lavage fluid and lowered blood TNF-alpha and IL-6, with downregulation of lung TLR4 and NF-kappa B protein. Blood ac…
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