A synthetic microRNA-92a inhibitor (MRG-110) accelerates angiogenesis and wound healing in diabetic and nondiabetic wounds.
MouseWounddb/db mice; normal pigs
Model: Excisional cutaneous wounds in db/db mice (chronic/diabetic) and in normal pigs (acute)
MRG-110 increased granulation tissue, angiogenesis and perfusion, and accelerated wound closure in both acute and chronic wounds, with effects greater than rhVEGF-165 and rhPDGF-BB and at least additive with rhPDGF-BB. No safety concerns were noted.
Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.