Resident Microglia Activate before Peripheral Monocyte Infiltration and p75NTR Blockade Reduces Microglial Activation and Early Brain Injury after Subarachnoid Hemorrhage.

Resident Microglia Activate before Peripheral Monocyte Infiltration and p75NTR Blockade Reduces Microglial Activation and Early Brain Injury after Subarachnoid Hemorrhage.

Model: Experimental subarachnoid haemorrhage with early brain injury

Activated microglia appeared in cortex by 24 h and increased at 48 and 72 h, while monocyte infiltration was not seen until 72 h. TAT-Pep5 significantly reduced microglial activation, neuroinflammation and early brain injury from 24 to 72 h.

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