Effect of Mannitol Infusion on Optic Nerve Injury After Acute Traumatic Subarachnoid Hemorrhage and Brain Injury.
RatTBIWeight-drop / impact-accelerationWistarMalen = 30 rats in total, 10 per groupIntravenous1 mg/kg
Model: Weight-drop impact acceleration traumatic brain injury with traumatic subarachnoid haemorrhage, assessing optic nerve injury
Optic nerve glutathione peroxidase was significantly higher and interleukin 1 beta significantly lower in the mannitol group than in the untreated injury group, suggesting protection of the optic nerve from secondary injury.
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