Cardioprotective role of FA against isoproterenol induced cardiac toxicity.
RatChemical/toxinSprague-DawleyOral10, 20 and 40 mg/kg body weightPre-treatment, given for 28 days before isoproterenol challenge
Model: Isoproterenol-induced acute cardiac toxicity, 85 mg/kg body weight subcutaneously on two consecutive days
Ferulic acid pre-treatment significantly attenuated the rise in serum cardiac enzymes, alleviated oxidative stress, augmented the endogenous antioxidant system and restored cellular architecture on histopathology, comparably to metoprolol.
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