Inhibition of MicroRNA-9-5p Protects Against Cardiac Remodeling Following Myocardial Infarction in Mice.
MouseIschaemia-reperfusionCardiacMale
Model: Murine acute myocardial infarction model; in vitro hypoxia in H9c2 cardiomyoblasts
In vivo silencing of miR-9-5p preserved post-infarction heart function with attenuated fibrosis and inflammation, stabilised Fstl1 expression and blocked cardiac cell death and reactive oxygen species generation. Cytoprotection by the miR-9-5p inhibitor was partially reversed by Fstl1 knockdown.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.