Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity.
MouseChemical/toxinC57Bl/6J background, PAR-1 wild-type and PAR-1 deficient cousin linesMaleOral gavage30 micrograms/kg stated in Methods; 30 mg/kg stated in Resu…One hour before doxorubicin injection and daily thereafter
Model: Doxorubicin-induced cardiotoxicity, acute model using a single intraperitoneal dose of 20 mg/kg with function assessed at 5 days, and chronic model using 5 mg/kg weekly for 5 weeks to a cumulative 25 mg/kg at 35 days
PAR-1 deficient mice showed less cardiac injury, oxidative stress, apoptosis and inflammation and better preserved cardiac function after both acute and chronic doxorubicin exposure, and vorapaxar treatment of wild-type mice reduced acute doxorubicin-induced cardiac dysfunction with no additional e…
Extraction: extract · Supplied extraction confidence: 0.82. Machine-extracted fields require source verification.