Pericytes reduce inflammation and collagen deposition in acute wounds.
MouseWoundnu/nu athymic nude (BALB/c background per MeSH indexing)Topical application of a cell sheet to the wound bed
Model: Full-thickness excisional dermal wounds on the dorsum
Pericyte sheets persisted in the wound to day 16, reduced wound size, enhanced neovascularisation and granulation tissue, raised collagen III relative to collagen I mRNA, produced thinner and better aligned collagen fibrils and lowered TNF-alpha mRNA compared with fibroblast-treated wounds.
Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.