Treatment with Trichilia catigua ethyl-acetate fraction improves healing and reduces oxidative stress in TNBS-induced colitis in rats.
RatChemical/toxinWistarMaleOral gavage or intrarectal200 mg/kgAdministered at different time points after TNBS challenge
Model: 2,4,6-trinitrobenzenesulphonic acid induced colitis, with severe colonic inflammation at 24 hours persisting to 7 days and myenteric neuron loss by 28 days
Treatment prevented the rise in blood oxidative stress within 24 hours and returned histological and macroscopic damage to control levels by day 7, with oral delivery more effective than intrarectal, but it did not prevent the loss of myenteric neurons at 28 days.
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