CBLB502, a Toll-like receptor 5 agonist, offers protection against radiation-induced male reproductive system damage in mice.
MouseRadiationC57BL/6; Tlr5 knockoutMaleIntraperitoneal0.2 mg/kg30 min before irradiation
Model: Whole-body ionising radiation at 5.0 Gy causing testicular injury
CBLB502 pre-treatment reduced radiation-induced oxidative stress, preserved seminiferous tubule architecture, sperm quantity and quality and fertility, lowered DNA damage and chromosomal aberrations, and reversed changes in testosterone, superoxide dismutase and malondialdehyde. Protection was abse…
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