ORLActivation Mediates a Novel ORLReceptor Agonist SCH221510 Analgesia in Neuropathic Pain in Rats.
RatOtherSprague-DawleyMaleIntrathecal3, 10 and 30 microgramTested on day 7 after chronic constriction injury surgery
Model: Chronic constriction injury of the sciatic nerve producing neuropathic pain
Intrathecal SCH221510 dose-dependently reduced thermal and mechanical hypersensitivity after chronic constriction injury. The analgesia was blocked by the ORL1 antagonist and by intrathecal ORL1 siRNA, indicating that it is mediated by spinal ORL1 activation.
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