Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice.

Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice.

Model: Controlled cortical impact traumatic brain injury

MP201 improved mitochondrial bioenergetics in the ipsilateral cortex and hippocampus at 25 h and reduced oxidative damage markers. At 2 weeks it increased cortical tissue sparing (p = 0.0059, 38% of lesion spared) and improved novel object recognition (p = 0.0133) versus vehicle, and preserved CA3…

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