Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice.

PMID 30056081 ↗2018Mixed findings

Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice.

MouseRadiationC57BL/6JMaleOral gavage120 mg/kg body weight, dissolved in sterile water at 10 mg/…28 and 4 h before irradiation (protective arm); or 4 and 24 h after 13 Gy (post…

Model: Gastrointestinal acute radiation syndrome from subtotal body irradiation with head and forelimbs shielded; single dose 15 Gy or 12 to 15 Gy for crypt survival, or fractionated 6 Gy or 6.5 Gy times 5 daily fractions, 320 kVp X-rays at 204 cGy/min

Palbociclib given 28 and 4 h before a single subtotal body irradiation dose significantly improved survival, gut barrier integrity and crypt survival, whereas the same drug given after irradiation had no effect. Given before and during five daily fractions it exacerbated gastrointestinal toxicity a…

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Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice.

Evidence by therapy association

Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice.