Nogo-A inhibits vascular regeneration in ischemic retinopathy.
MouseIschaemia-reperfusionOther / unspecifiedC57BL/6Acute inhibition after oxygen-induced retinopathy; exact timing not stated in t…
Model: Oxygen-induced retinopathy, producing defined zones of retinal ischaemia
Acute inhibition of Nogo-A with the function-blocking antibody 11C7 significantly improved vascular regeneration, prevented pathological pre-retinal angiogenesis and restored retinal function measured electrophysiologically.
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