Lam. Decreases Oxidative Stress in Blood Cells and Prevents Doxorubicin-Induced Cardiotoxicity.
MixedChemical/toxinC57BL/6Male (cardiotoxicity study); female (acute toxicity study)n = n=5 per group (control, doxorubicin, doxorubicin plus GUEsb…Oral200 mg/kg body mass in the cardioprotection study; 2000 and…Extract started at the beginning of the experiment, 6 days before the first dox…
Model: Doxorubicin-induced cardiotoxicity, cumulative 24 mg/kg intraperitoneally divided into six alternate-day doses on days 7, 9, 11, 13, 15 and 17, euthanasia on day 18
Doxorubicin raised cardiac malondialdehyde by about 48 per cent versus control, and co-treatment with 200 mg/kg oral GUEsb prevented this rise, giving malondialdehyde 19 per cent below control. The extract showed no acute toxicity at 2000 or 5000 mg/kg apart from raised creatinine at the highest do…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.