Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury.
MouseEndotoxin/LPSICR (imprinting control region)MaleIntravenous, tail veinPassage 3 cells in 100 microlitres PBS per mouse; exact cel…6 h after intratracheal LPS
Model: Lipopolysaccharide-induced acute lung injury, 2 mg/kg LPS O55:B5 in 100 microlitres PBS intratracheally under pentobarbital anaesthesia
Both umbilical cord and menstrual blood mesenchymal stem cells reduced lung injury score, oedema, lavage cellularity and protein, myeloperoxidase and pro-inflammatory cytokines while improving oxygenation. Umbilical cord cells were consistently more effective, with lung injury score 6.7 plus or min…
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