Dextran-based biodegradable nanoparticles: an alternative and convenient strategy for treatment of traumatic spinal cord injury.
RatSpinal cord injuryContusionSprague Dawleyfemalen = n=8 rats in the spinal cord injury control group; four grou…Intrathecal injection approximately 1 mm rostral and caudal to the lesion epicentre; Taxol delivered by implanted Alzet miniosmotic pumpAbout 15 microgram paclitaxel as PTX@Ac-DEX diluted in 10 m…Within 5 minutes after trauma for nanoparticle and vehicle groups
Model: T10 laminectomy followed by weight drop contusion using a 10 g rod (2.5 mm diameter) dropped from 12.5 mm
Both PTX@Ac-DEX and Taxol improved BBB locomotor scores from the first week after surgery to sacrifice at week 4 relative to injury and empty nanoparticle controls, reduced loss of NF200 staining and reduced CS56 (CSPG) deposition at the lesion. GFAP intensity did not differ between groups. A singl…
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