Cypin: A novel target for traumatic brain injury.
MouseTBIControlled cortical impactC57BL/6MaleDirect intrahippocampal injection, ipsilateral hippocampus (X -1.9, Y 1.4, Z -1.6)200 micromolar in artificial cerebrospinal fluid vehicle, 1…One hour after cortical impact
Model: Controlled cortical impact over the left parietotemporal cortex with dura intact; mild (1.0 mm depth, 0.4-0.5 m/s) and moderate (1.0 mm depth, 2.4-5.0 m/s) severities, behavioural work used moderate impact
Both cypin activators significantly improved freezing behaviour five days after injury relative to vehicle injured and untreated injured mice (H9 versus vehicle injured p<0.0001; G5 versus vehicle injured p=0.0022), whereas the inhibitor B9 gave no improvement (p>0.9).
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.