Photobiomodulation and different macrophages phenotypes during muscle tissue repair.
RatCrushLimb / muscle crushWistarMalen = 50 rats in total, 15 per injured group and 5 per group per…Transcutaneous contact irradiation at 90 degrees over 8 points surrounding the sutured areaBeam area 0.04 cm2, power output 70 mW, power density 1750…First session 2 hours after cryoinjury
Model: Cryoinjury of the tibialis anterior muscle using a liquid nitrogen cooled metal rod of 3 mm diameter applied to the ventral muscle surface for 10 s, thawed and repeated for 10 s, then sutured
Both wavelengths reduced myonecrosis and inflammatory cell infiltration and CD68 positive M1 macrophages at day 2, while only near infrared light increased CD206 positive M2 macrophages at day 2 (p=0.0001), blood vessel numbers and immature muscle fibres at day 7 (p=0.0089).
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.