Scarless Wound Closure by a Mussel-Inspired Poly(amidoamine) Tissue Adhesive with Tunable Degradability.
RatWoundSprague DawleyMalen = 15 rats, three groups of five; histology n=3Topical to the wound opening50 microlitres of CPAA tissue glue applied to the wound and…Immediately at wound closure
Model: Full skin thickness incisional wound 1.5 cm long on the dorsum, closed immediately under isoflurane and oxygen anaesthesia
At day 28 scar area was 0.13 +/- 0.00 mm2 with the adhesive versus 0.83 +/- 0.01 mm2 for suture and 0.24 +/- 0.02 mm2 for fibrin glue, with lower collagen intensity (0.30 +/- 0.02 versus 0.44 +/- 0.02 and 0.42 +/- 0.02, p<0.05).
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.