In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury.
MouseChemical/toxinMalen = n=6 per group for the rGDF3 treatment experimentIntramuscularSingle intramuscular dose of 300 ng; figure legend also rep…Day 4 after cardiotoxin injury
Model: Cardiotoxin-induced acute sterile injury of the tibialis anterior muscle
A single intramuscular dose of rGDF3 restored myofibre cross-sectional area and the morphological features of regenerating aged muscle at day 8, with no obvious enhancement in young mice.
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