PRECLINICAL PUBLICATION · 2018

Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing.

Mouse / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Fibroblastic reticular cell administration, with lymphotoxin beta receptor immunoglobulin fusion protein and fibroblastic reticular cell depletion as mechanistic interventions

PMID 29997302 ↗2018Mixed findings

Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing.

MouseIschaemia-reperfusionRenalC57BL/6Male

Model: Renal ischaemia-reperfusion injury including a repetitive ischaemia-reperfusion protocol; procedural detail not stated

Chronic fusion protein treatment altered the kidney draining lymph node and augmented renal fibrosis, depletion of fibroblastic reticular cells reduced lymph node T cell activation and ameliorated acute injury, and administration of fibroblastic reticular cells ameliorated lymph node fibrosis and r…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.