Recombinant Leucine-Rich Repeat Flightless-Interacting Protein-1 Improves Healing of Acute Wounds through Its Effects on Proliferation Inflammation and Collagen Deposition.
MouseWoundBALB/c wild typeFemaleIntradermal into the wound marginsSingle intradermal injection of 100 microlitres of recombin…At the time of wounding; an explicit interval after injury is not stated
Model: Two full-thickness 1 cm incisional wounds on the dorsum, harvested at days 3, 7 and 14
Wounds treated with rLRRFIP-1 were significantly smaller and more contracted at day 7 with improved re-epithelialisation, reduced TLR4 and inflammatory cell infiltration, and more than 40% higher total collagen at day 7 at the 1 microgram/ml dose, with no difference between the two doses.
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