PRECLINICAL PUBLICATION · 2018

Knockdown of lncRNA BDNF-AS suppresses neuronal cell apoptosis via downregulating miR-130b-5p target gene PRDM5 in acute spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

lncRNA BDNF-AS knockdown

PMID 29995562 ↗2018Reported benefit

Knockdown of lncRNA BDNF-AS suppresses neuronal cell apoptosis via downregulating miR-130b-5p target gene PRDM5 in acute spinal cord injury.

RatSpinal cord injuryUnspecifiedSprague-DawleyMale

Model: Rat model of acute spinal cord injury, with a parallel hypoxic neuronal cell model in vitro

BDNF-AS, PRDM5 and cleaved caspase 3 were raised and miR-130b-5p lowered after acute spinal cord injury; BDNF-AS knockdown reduced neuronal apoptosis through the miR-130b-5p/PRDM5 axis.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.