Quetiapine protects the blood-brain barrier in traumatic brain injury.
MixedTBIControlled cortical impactC57BL/6Malen = 5 animals per groupIntravenous in vivo; culture medium in vitro10 mg/kg in vivo; 20 micromolar for cell studies10 minutes after traumatic brain injury in vivo; 1 h pretreatment before chitos…
Model: Mild to moderate controlled cortical impact traumatic brain injury, with sham craniotomy controls; in vitro chitosan-activated endothelial hyperpermeability
Quetiapine significantly reduced blood-brain barrier hyperpermeability and matrix metalloproteinase-9 activity after traumatic brain injury and preserved tight and adherens junction integrity in vitro.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.