Aldehyde dehydrogenase 2 activation ameliorates cyclophosphamide-induced acute cardiotoxicity via detoxification of toxic aldehydes and suppression of cardiac cell death.
MouseChemical/toxinC57BL/6 wild type and aldehyde dehydrogenase 2 knockoutPretreatment before cyclophosphamide administration
Model: High-dose cyclophosphamide-induced acute cardiotoxicity
Aldehyde dehydrogenase 2 knockout mice were more susceptible to cyclophosphamide cardiotoxicity, and Alda-1 pretreatment markedly reduced toxic aldehyde accumulation, cardiac cell death and cardiac dysfunction without reducing the antitumour effect of cyclophosphamide.
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