Decorin-Modified Umbilical Cord Mesenchymal Stem Cells (MSCs) Attenuate Radiation-Induced Lung Injuries via Regulating Inflammation, Fibrotic Factors, and Immune Responses.
MouseRadiationC57BL/6MaleIntravenous engraftment6 hours after irradiation (acute phase) or 28 days after irradiation (later pha…
Model: Experimental mouse model of radiation-induced lung injury following gamma irradiation
Both mesenchymal stem cell treatments reduced lymphocyte infiltration, apoptosis and later fibrosis, with decorin-modified cells clearly more effective, and treatment at 6 hours produced stronger responses than treatment at 28 days.
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