Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury.
RatRadiationSprague-DawleyMalen = 33 adult male rats in total (4 normal, 18 irradiated, remai…Intravenous injection via the tail veinAfter the 5-day irradiation period and removal of the seeds
Model: Acute radioactive oesophageal injury induced in vivo by five iodine-125 seeds of 0.8 mCi initial activity placed at 8 cm depth in a disposable ureteral catheter in the oesophageal lumen for 5 days, giving a central dose rate of 43 cGy/h; sham group received the catheter without seeds
Mean oesophageal epithelial thickness rose to 62.35 plus or minus 1.99 micrometres in the dental pulp stem cell group against 27.11 plus or minus 2.92 micrometres in controls and 25.71 plus or minus 1.90 micrometres in sham animals; inflammatory cytokines fell to sham levels and food intake was sig…
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