Pifithrin-mu modulates microglial activation and promotes histological recovery following spinal cord injury.
MouseSpinal cord injuryContusionC57BL/6FemaleAdministered during the acute phase of injury
Model: Spinal cord contusion injury
Pifithrin-mu attenuated microglial activation in vitro and, given during the acute phase, reduced lesion size and the number of pro-inflammatory microglia and macrophages, maintaining a more anti-inflammatory environment after a single dose.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.