Interleukin 15 blockade protects the brain from cerebral ischemia-reperfusion injury.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6 (wild type and Il15 knockout)MaleAfter ischaemia-reperfusion
Model: Cerebral ischaemia-reperfusion (experimental ischaemic stroke)
Il15 knockout mice had smaller infarcts and fewer activated infiltrating lymphocytes. Post-ischaemia IL-15 blockade reduced infarct size, improved motor and locomotor activity and reduced effector function of NK, CD8 T and CD4 T cells.
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