Inhaled TRIM72 Protein Protects Ventilation Injury to the Lung through Injury-guided Cell Repair.
MouseOtherInhalation by nebulisation
Model: Ventilator-induced lung injury by injurious ventilation at 30 ml/kg tidal volume, with in vitro glass bead and stretch injury of alveolar epithelial cells
Exogenous rhT72 preserved alveolar epithelial membrane integrity in a dose-dependent manner in vitro, and inhaled rhT72 reduced the number of fatally injured alveolar cells and ameliorated tissue damage and cell injury markers after injurious ventilation.
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