von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury.
MouseTBIFluid percussionMaleGiven either before or after traumatic brain injury
Model: Fluid percussion traumatic brain injury
Recombinant ADAMTS-13 given before or after injury reduced VWF reactivity with minimal effect on VWF secretion, protected endothelial barrier integrity and prevented injury-induced coagulopathy by enhancing VWF cleavage without impairing basal haemostasis. Promoting microvesicle clearance with lact…
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