Anti-hyperalgesic effects of two sphingosine derivatives in different acute and chronic models of hyperalgesia in mice.
MouseChemical/toxinSwissMaleOral0.3 to 3 mg/kgPre-treatment 1 h before the inflammatory stimulus
Model: Carrageenan, lipopolysaccharide, bradykinin, prostaglandin E and epinephrine induced mechanical hypersensitivity; complete Freund's adjuvant persistent inflammatory pain; partial sciatic nerve ligation neuropathic pain
Both AA and OA reduced hypersensitivity induced by carrageenan, lipopolysaccharide and bradykinin. OA produced modest inhibition of prostaglandin E induced hypersensitivity and of carrageenan-induced paw oedema. When dosed once daily, both compounds significantly reduced persistent inflammatory (co…
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